Total de pilots participants: 88 (33 a Indianapolis)
Total d’equips participants: 65 (29 a Indianapolis)
Debutants: 30 (Red Amick, Chuck Arnold, Peter Ashdown, Lucien Bianchi, Harry Blanchard, Don Branson, Chris Bristow, Nicha Cabral, Phil Cade, Alain de Changy, George Constantine,Colin Davis, Azdrubal Fontes, Keith Greene, Bobby Grim, Dan Gurney, Innes Ireland, Pete Lovely, Jean Lucienbonnet, Jim McWithey, Bill Moss, Fritz d’ Orey, Mike Parkes, Tim Parnell, David Piper, Bob Said, Dennis Taylor, Henry Taylor, Mike Taylor, Trevor Taylor)
Última temporada: 29 (Chuck Arnold, Peter Ashdown, Jean Behra, Harry Blanchard, Ivor Bueb, Phil Cade, Alain de Changy, Bill Cheesbourg, George Constantine, Ray Crawford, Colin Davis, Jimmy Daywalt, Maria Teresa de Filippis, Pat Flaherty, Azdrubal Fontes, Al Keller, Jud Larson, Jean Lucienbonnet, Mike Magill, Bill Moss, Fritz d’ Orey, Paul Russo, Bob Said, Carroll Shelby, Dennis Taylor, André Testut, Alejandro de Tomaso, Jack Turner, Chuck Weyant)
Defuncions a la F1: 0
Defuncions en altres categories: 2 (Jean Behra, Ivor Bueb)
Defuncions no relacionades amb l’esport: 0
Retirats per lesions a la F1: 0
Retirats per lesions a la F1: 0
Retirats per lesions en altres categories: 0
Pilot més jove: Fritz d’Orey, 21 anys i 107 dies, França
Pilot més vell: Jack Fairman, 46 anys i 193 dies, Itàlia
| Entrant | Cotxe | Pneu. | Pilots |
| David Brown Corporation | Aston Martin DBR4 | A | Roy Salvadori Carroll Shelby |
| Scuderia Ferrari | Ferrari 246 Ferrari 156 |
D | Jean Behra Tony Brooks Cliff Allison Wolfgang von Trips Phil Hill Dan Gurney Olivier Gendebien |
| Cooper Car Company | Cooper T51-Climax | D | Jack Brabham Bruce McLaren Masten Gregory Giorgio Scarlatti |
| Scuderia Centro Sud | Maserati 250F Cooper T51-Maserati |
D | Hans Herrmann Ian Burgess Colin Davis Nicha Cabral Fritz d’Orey Azdrubal Fontes |
| Team Lotus | Lotus 16-Climax | D | Graham Hill Innes Ireland Alan Stacey Pete Lovely |
| Connaught Cars Paul Emery |
Connaught C-Alta | D | Bob Said |
| Vandervell Products | Vanwall VW59 | D | Tony Brooks |
| Owen Racing Organisation | BRM P25 | D | Ron Flockhart Jo Bonnier Harry Schell |
| R. R. C. Walker Racing Team |
Cooper T51-Climax | D | Stirling Moss Maurice Trintignant |
| Dr. Ing. F. Porsche KG | Porsche 718 RSK Porsche 718/2 |
D | Wolfgang von Trips |
| Ecurie Maarsbergen | Porsche 718 RSK | D | Carel Godin de Beaufort |
| J. B. Naylor | JBW 59-Maserati | D | Brian Naylor |
| David Fry | Fry F2-Climax | D | Mike Parkes |
| M. T. de Filippis | Behra-Porsche RSK | D | Maria Teresa de Filippis |
| Jean Behra | Behra-Porsche RSK | D | Jean Behra |
| Scuderia Ugolini | Maserati 250F | D | Giorgio Scarlatti Carel Godin de Beaufort |
| Monte Carlo Auto Sport | Maserati 250F | D | André Testut |
| Ottorino Volonterio | Maserati 250F | D | Ottorino Volonterio |
| Phil Cade | Maserati 250F | D | Phil Cade |
| Camoradi USA | Tec-Mec F415-Maserati | D | Fritz d’Orey |
| British Racing Partnership | Cooper T51-Climax Cooper T51-Borgward BRM P25 |
D | Stirling Moss Chris Bristow Ivor Bueb Hans Herrmann |
| R. H. H. Parnell | Cooper T45-Climax Cooper T51-Climax |
D | Henry Taylor Tim Parnell |
| OSCA Automobili | Cooper T43-OSCA | D | Alejandro de Tomaso |
| High Efficiency Motors | Cooper T45-Climax Cooper T45-Maserati |
D | Roy Salvadori Jack Fairman |
| Equipe Nationale Belge | Cooper T51-Climax | D | Lucien Bianchi Alain de Changy |
| John Fisher | Lotus 16-Climax | D | Bruce Halford |
| Dennis Taylor | Lotus 12-Climax | D | Dennis Taylor |
| Dorchester Station | Lotus 16-Climax | D | David Piper |
| Ace Garage-Rotherham | Cooper T51-Climax | D | Trevor Taylor |
| Alan Brown Equipe | Cooper T45-Climax | D | Mike Taylor Peter Ashdown |
| Gilby Engineering | Cooper T45-Climax | D | Keith Greene |
| United Racing Stable | Cooper T51-Climax | D | Bill Moss |
| Taylor-Crawley Racing Team |
Cooper T51-Climax | D | George Constantine |
| Jean Lucienbonnet | Cooper T45-Climax | D | Jean Lucienbonnet |
| Equipe Bleue | Cooper T51-Climax | D | Harry Schell |
| Leader Cards Inc. | Kurtis Kraft Midget-Offy Watson-Offy |
F | Rodger Ward |
| Blanchard Automobile Co. | Porsche 718 RSK | F | Harry Blanchard |
| Bignotti-Bowes Racing | Epperly-Offy Kurtis Kraft-Offy |
F | Johnny Boyd Jud Larson |
| John R. Wills | Epperly-Offy | F | Tony Bettenhausen |
| Wolcott Memorial Racing Team |
Lesovsky-Offy | F | Len Sutton |
| Ernest L. Ruiz | Christensen-Offy | F | Jack Turner |
| George Salih | Salih-Offy | F | Jimmy Bryan |
| Yunick, Glover & Lathrop | Kurtis Kraft-Offy | F | Duane Carter |
| Lysle Greenman | Kuzma-Offy | F | Bill Cheesbourg |
| J. S. Donaldson | Kurtis Kraft 500G-Offy | F | Eddie Johnson |
| Racing Associates | Lesovsky-Offy | F | Johnny Thomson |
| Fred Gerhardt | Kurtis Kraft 500G-Offy | F | Paul Russo |
| Ray Crawford | Elder-Offy | F | Ray Crawford |
| George Walther Jr. | Sutton-Offy | F | Mike Magill |
| Lindsey Hopkins | Watson-Offy | F | Jim Rathmann |
| Bob Estes | Phillips-Offy | F | Don Branson |
| Ray T. Brady | Kurtis Kraft 500C-Offy | F | Jim McWithey |
| Chapman S. Root | Kurtis Kraft 500G-Offy | F | Bobby Grim |
| Karl Hall | Kurtis Kraft-Offy | F | Chuck Arnold |
| Roy McKay | Kurtis Kraft 500G-Offy | F | Chuck Weyant |
| A. E. Dean | Kuzma-Offy | F | A. J. Foyt |
| Peter Schmidt | Kuzma-Offy | F | Eddie Sachs |
| John Zink | Moore-Offy | F | Bob Veith Pat Flaherty |
| LeRoy E. Foutch Jr. | Kurtis Kraft 500C-Offy | F | Red Amick |
| Federal Auto Associates | Kurtis Kraft 500C-Offy | F | Bob Christie Jimmy Daywalt |
| H. H. Johnson | Kuzma-Offy | F | Al Keller |
| Jim Robbins | Kurtis Kraft 500G-Offy | F | Don Freeland |
| Kalamazoo Sports Inc. | Watson-Offy | F | Dick Rathmann |
| Harry Dunn | Dunn-Offy | F | Al Herman |
| Norman C. Demler | Epperly-Offy | F | Paul Goldsmith |
| R. T. Marley Sr. | Kuzma-Offy | F | Gene Hartley |