Total de pilots participants: 78 (33 a Indianapolis)
Total d’equips participants: 48 (27 a Indianapolis)
Debutants: 16 (Ivor Bueb, Bill Cheesbourg, Don Edmunds, Paul England, Elmer George, Dick Gibson, Carel Godin de Beaufort, Masten Gregory, Stuart Lewis-Evans, Mike MacDowel, Herbert MacKay-Fraser, Mike Magill, Tony Marsh, Brian Naylor, Eddie Sachs,Alessandro de Tomaso)
Última temporada: 17 (Fred Agabashian, Eugenio Castellotti, Don Edmunds, Paul England, Elmer George, Bob Gerard, Sam Hanks, Les Leston, Andy Linden, Mike MacDowel, Herbert MacKay-Fraser, Umberto Maglioli, Cesare Perdisa, Alfonso de Portago, André Simon, Marshall Teague, Ottorino Volonterio)
Defuncions a la F1: 0
Defuncions en altres categories: 3 (Eugenio Castellotti, Herbert MacKay-Fraser, Alfonso de Portago)
Defuncions no relacionades amb l’esport: 0
Retirats per lesions a la F1: 0
Retirats per lesions a la F1: 0
Retirats per lesions en altres categories: 1 (Andy Linden)
Pilot més jove: Carel Godin de Beaufort, 23 anys i 122 dies, Alemanya
Pilot més vell: Juan Manuel Fangio, 46 anys i 88 dies, Itàlia
| Entrant | Cotxe | Pneu. | Pilots |
| Officine Alfieri Maserati | Maserati 250F | P | Giorgio Scarlatti Juan Manuel Fangio Carlos Menditéguy Stirling Moss Jean Behra Harry Schell Hans Herrmann |
| Scuderia Ferrari | Ferrari 801 | E P |
Eugenio Castellotti Luigi Musso Cesare Perdisa Peter Collins Mike Hawthorn Froilán González Alfonso de Portago Wolfgang von Trips Maurice Trintignant |
| Cooper Car Company | Cooper T43-Climax | D A |
Jack Brabham Les Leston Roy Salvadori Mike MacDowel |
| Scuderia Centro Sud | Maserati 250F Ferrari 500 |
P | Alejandro de Tomaso Harry Schell Masten Gregory Hans Herrmann André Simon Jo Bonnier |
| Connaught Engineering | Connaught B-Alta | D | Stuart Lewis-Evans Ivor Bueb |
| Vandervell Products | Vanwall VW5 | P | Stirling Moss Tony Brooks Stuart Lewis-Evans Roy Salvadori |
| Owen Racing Organisation | BRM P25 | D | Ron Flockhart Roy Salvadori Jack Fairman Les Leston Herbert MacKay-Fraser |
| R. R. C. Walker Racing Team |
Cooper T43-Climax | D | Jack Brabham |
| Dr. Ing. F. Porsche KG | Porsche RS550 | D | Umberto Maglioli Edgar Barth |
| Ecurie Maarsbergen | Porsche RS550 | D | Carel Godin de Beaufort |
| Jo Bonnier | Maserati 250F | P | Jo Bonnier |
| Ridgeway Management | Cooper T41-Climax Cooper T43-Climax |
D | Tony Marsh Paul England |
| J. B. Naylor | Cooper T43-Climax | D | Brian Naylor |
| Dick Gibson | Cooper T43-Climax | D | Dick Gibson |
| Francesc Godia Sales | Maserati 250F | P | Paco Godia |
| H. H. Gould | Maserati 250F | D | Horace Gould |
| Bob Gerard | Cooper T44-Bristol | D | Bob Gerard |
| Luigi Piotti | Maserati 250F | P | Luigi Piotti |
| Gilby Engineering | Maserati 250F | D | Ivor Bueb |
| Bruce Halford | Maserati 250F | D | Bruce Halford |
| Ottorino Volonterio | Maserati 250F | P | Ottorino Volonterio André Simon |
| Fred & Richard Sommer | Kurtis Kraft 500C-Offy | F | Jimmy Reece |
| Pat Clancy | Kurtis Kraft 500G-Offy | F | Jack Turner Al Keller |
| Roger Wolcott | Lesovsky-Offy | F | Rodger Ward |
| George Bignotti | Kurtis Kraft 500G-Offy | F | Johnny Boyd Fred Agabashian |
| George Salih | Salih-Offy | F | Sam Hanks |
| Joseph Massaglia Jr. | Lesovsky-Offy | F | Gene Hartley |
| Lysle Greenman | Kuzma-Offy | F | Johnnie Tolan |
| J. S. Donaldson | Kurtis Kraft 500G-Offy | F | Bill Cheesbourg |
| Racing Associates | Kuzma-Offy | F | Johnny Thomson |
| Fred Sclavi | Kurtis Kraft 500C-Offy | F | Eddie Russo |
| H. A. Chapman | Kurtis Kraft 500G-Offy | F | Eddie Johnson |
| George Walther Jr. | Kurtis Kraft 500G-Offy | F | Mike Magill |
| Lindsey Hopkins | Epperly-Offy | F | Jim Rathmann |
| Bob Estes | Phillips-Offy | F | Bob Veith |
| Ansted Rotary Co. | Kurtis Kraft 500D-Offy | F | Don Freeland |
| Chapman S. Root | Kurtis Kraft 500G-Offy Kurtis Kraft 500D-Offy |
F | Johnnie Parsons Pat O’Connor Marshall Teague |
| Cars Inc. | Kurtis Kraft 500C-Offy | F | Bob Christie |
| Roy McKay | Kurtis Kraft 500G-Offy | F | Don Edmunds |
| A. E. Dean | Kuzma-Offy | F | Jimmy Bryan |
| Peter Schmidt | Kuzma-Offy | F | Eddie Sachs |
| John Zink | Watson-Offy | F | Troy Ruttman |
| Novi Racing Co. | Kurtis Kraft-Novi | F | Tony Bettenhausen Paul Russo |
| Ernest L. Ruiz | Kurtis Kraft 500B-Offy | F | Elmer George |
| H. H. Johnson | Kurtis Kraft 500C-Offy | F | Jimmy Daywalt |
| Pete Salemi | Kuzma-Offy | F | Chuck Weyant |
| Kalamazoo Sports Inc. | Kurtis Kraft 500C-Offy Kurtis Kraft 500G-Offy |
F | Ed Elisian Andy Linden |
| Harry Dunn | Dunn-Offy | F | Al Herman |